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Whilst vitamin B12 toxicity is exceptionally rare due to its water-soluble nature, very high levelsparticularly from mega-dose supplements or frequent injectionshave been associated with certain adverse effects, most notably skin reactions

It is done under general anesthesia

Increased Requirements: Rapidly replenishes B vitamin levels during periods of high metabolic demand, such as post-surgery or chronic stress

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[23] Sip on a warm drink, slip into a sweater, or hop into a warm shower before you need to inject your medicine